Diagnostics and Risk Profiling: Predicting Disease

Diagnostics is the science of identifying a genetic predisposition for disease in pre-symptomatic individuals, and a critical element to enable early detection, prevention and administration of therapeutic treatments. The technology for detecting changes in DNA and protein associated with disease has undergone rapid development. High throughput techniques to identify single nucleotide polymorphisms (SNPs) and other types of mutations have been developed. For example, extensive catalogues of SNPs across the genome have been constructed and microarray and other methods to interrogate large numbers of samples have been introduced into the marketplace. These methods are increasingly used as a means to investigate the genetic etiology of complex human diseases.

The identification of a SNP or SNP-based haplotype closely associated with a human disease is the focus of intense efforts designed to allow the use of this information to develop diagnostic tests. Early detection and risk profiling will be of great benefit in many human diseases and promises to dramatically enhance our ability to study the inter-relationships of genetic and environmental risk factors for disease.

Diagnostics is one of the fastest growing branches of modern day genomics. Combining modern knowledge of the human genome and proteome with state of the art information technology, diagnostics seeks to allow the prediction of genetic susceptibility and onset timing of disease. Common human diseases that are the subject of such research efforts include asthma, heart disease, leukemia, juvenile diabetes, mental illness, alcoholism, Alzheimer's disease, and various cancers. The early detection of complex diseases through genetic testing will allow the development of proactive, prophylactic therapies that promise to increase disease survivability dramatically.

Triaj offers expertise at the highest levels in a broad range of services related to diagnostics, from general advisory and project review to large scale applied consulting projects. Triaj's biotechnology professionals are recognized international leaders in their fields, and include experts in genetics, genomics, proteomics, molecular biology, genetic statistics, clinical epidemiology, genetic epidemiology, biostatistics, bioinfomatics, diagnostics, therapeutics, and gene mapping.

Triaj's professional staff has an unparalleled wealth of expertise in all aspects of diagnostic technology development and SNP genotyping, including study design, clinical data collection, molecular methodologies, and biostatistical analysis for both detection and treatment of disease.

Profit from Triaj's experience.

Triaj's professional staff collectively has over two hundred published articles in peer reviewed scientific journals and are the inventors of multiple patents of direct relevance to diagnostics and risk-profiling using genetic data. Triaj's professional staff has also published over 4,000 articles in peer-reviewed scientific literature in the related fields of clinical epidemiology, clinical genetics genetic epidemiology, statistical methodology, bioinformatics, pharmacogenomics, functional genomics, and gene discovery. Our professionals have extensive experience in clinical trials and in consulting to industry in this area.

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