Gene Mapping: Identifying the Genes

Gene mapping is the science of gene identification. In the past decade, the genomes of many plants and animals has been sequenced, culminating in the recently published Human Genome Project's sequencing of the entire human genome. An important goal of the ongoing Human Genome Project is the identification of genes from genomic sequence data, and more particularly, of genes associated with susceptibility to specific human diseases.

The sequencing of the entire human genome, which is being vigorously pursued both by government and industry, is providing a wealth of new information as to genetic structure and diversity. The construction of genetic maps, together with sophisticated statistical techniques, has allowed the identification of specific genes and proteins that contribute to risk for complex human diseases.

During the last decade, the genetic causes of common, complex human diseases have provided new insights into their causes. The ultimate goal of this is to improve preventive strategies, diagnostic tools and therapies. Considerable effort and expense is currently being expended in attempts to detect genetic loci contributing to human disease susceptibility. Associated technical developments have occurred in molecular genetics and in the use of polymorphism directly derived from DNA sequence, and extensive catalogues of DNA sequence variants across the human genome have begun to be constructed.

Public and industry genome projects have led to the identification of over 100 disease-causing genes, the majority of which are genes for single gene ('monogenic') disorders. These projects continue to identify defective genes, and are working to identify complex disease-causing gene combinations, such as those that contribute to diabetes, asthma, cancer, and mental illness.

Identifying defective genes and disease-causing gene combinations will lead to commercially viable genetics based diagnostics and therapies for human diseases. These are early stage endeavors with tremendous growth potential.

Triaj offers a broad range of services related to gene discovery, ranging from general advisory and project review to large scale applied consulting projects. Triaj's biotechnology professionals are recognized international leaders in their fields, and include experts in genetics, genomics, proteomics, molecular biology, genetic statistics, clinical epidemiology, genetic epidemiology, biostatistics, bioinfomatics, diagnostics, therapeutics, and gene mapping. Triaj's professional staff has an unparalleled wealth of expertise in all aspects of gene discovery, including study design, clinical data collection, generation of molecular data, and biostatistical analysis for mapping both single gene disorders and complex diseases.

Profit from Triaj's experience.

Triaj's professional staff collectively has over 2,000 published articles in peer reviewed scientific journals of direct relevance to methodological and applied issues in human gene discovery. More generally, Triaj's professional staff has over 4,000 published articles in the peer-reviewed scientific literature in the related fields of clinical epidemiology, clinical genetics, genetic epidemiology, statistical methodology, bioinformatics, pharmacogenomics, and functional genomics.

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