Functional Genomics: Networks of Genes

Functional genomics investigates gene function in disease processes or in response to therapy. Methods to simultaneously examine the effects of thousands of genes have only recently been commercialized under the name of "gene chips" or "microarrays." This area of biotechnology is rapidly exploding, and holds enormous commercial opportunities.

Gene expression analysis is being employed at all stages in clinical investigations. Uses include creating clinical profiles based on comparison of diseased versus normal states, identifying and developing new drug targets, testing for drug toxicity, producing diagnostic forecasts, and monitoring patient therapy or recovery. Gene expression data are being used to create clinical profiles of patients that do and do not respond to therapy. Recently, gene expression data were used to distinguish between two types of cancer that responded differently to therapy, but were indistinguishable using standard pathology analysis.

The potential for using gene expression analyses to generate diagnostic or prognostic forecasts for diseases is enormous, providing significant commercial opportunities. Timing, efficacy and response to treatment can eventually be monitored using microarrays; microarray-based technologies are likely to replace many current diagnostic methods.

Triaj offers a broad range of services related to functional genomics, ranging from general consulting and project review to large scale applied consulting projects. Triaj's team of biotechnology professionals are recognized international leaders in their fields, and includes experts in genetics, genomics, proteomics, molecular biology, genetic statistics, clinical epidemiology, genetic epidemiology, biostatistics, bioinfomatics, diagnostics, therapeutics, and gene mapping. Triaj's professional staff has an unparalleled wealth of expertise in all aspects of bioinformatics, including study design, database construction and management, analysis of microarray data, and biostatistical analysis.

Profit from Triaj's experience.

Triaj's professional staff collectively has over 500 published articles in peer reviewed scientific journals of direct relevance to functional genomics. More generally, Triaj's staff has over 4,000 published articles in the peer-reviewed scientific literature in the related fields of clinical epidemiology, clinical genetics, genetic epidemiology, statistical methodology, pharmacogenomics, functional genomics, and gene discovery. Our consultants also have extensive experience in the analysis of gene expression data and in consulting to industry in this area.

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